WEKO3
アイテム
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個人の組織から分離された繊維芽細胞及びそれらから作成されたiPS細胞のエピジェネティッククロック解析
https://nagoya-wu.repo.nii.ac.jp/records/4313
https://nagoya-wu.repo.nii.ac.jp/records/43130652ca58-a542-495f-83a4-d1952e0112dd
名前 / ファイル | ライセンス | アクション |
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kojinkasei65_27-38 (518.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-10-10 | |||||
タイトル | ||||||
タイトル | 個人の組織から分離された繊維芽細胞及びそれらから作成されたiPS細胞のエピジェネティッククロック解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Epigenetic Clock Analysis of Fibroblasts Prepared From a Single Donor and iPS Cells Derived from the Fibroblasts | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
堀江, 信之
× 堀江, 信之× 高橋, 和利× 加治, 和彦 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We performed Epigenetic Clock(EC) analysis of ASF-4 cells, which were derived from a single donor at different ages over 30 years. Optimization using a function of MethylAger software was performed and we demonstrated that it is possible to estimate the ages from methylation sites for both ASF-4 cells and iPS cells prepared from ASF-4 cells. For ASF- 4 cells, iPS cells, and all the cells, we were able to select three to eight methylation sites, from which the donor ages were estimated with a root mean squared error of fewer than 6 years. Methylation sites obtained by analysis of EC tend to exist in the vicinity of genes, and these genes contained genes related to aging that have been reported so far. Since it was possible to estimate age not only for fibroblasts but also for iPS cells derived from them, it is suggested that some age-dependent methylation sites exist even in the iPS cells. It is also suggested that analysis of the epigenetic clock is valuable as a method to identify genes related to aging involving DNA methylation. |
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書誌情報 |
名古屋女子大学紀要. 家政・自然編, 人文・社会編 号 65, p. 27-38, 発行日 2019-03 |
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出版者 | ||||||
出版者 | 名古屋女子大学 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-7962 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12530109 |