{"created":"2023-06-20T15:27:36.376196+00:00","id":4313,"links":{},"metadata":{"_buckets":{"deposit":"1863212b-a68b-486c-9ae6-4367d5d00b55"},"_deposit":{"created_by":14,"id":"4313","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"4313"},"status":"published"},"_oai":{"id":"oai:nagoya-wu.repo.nii.ac.jp:00004313","sets":["6:235"]},"author_link":["16753","16754","16755"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"65","bibliographicPageEnd":"38","bibliographicPageStart":"27","bibliographic_titles":[{"bibliographic_title":"名古屋女子大学紀要. 家政・自然編, 人文・社会編"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　We performed Epigenetic Clock（EC） analysis of ASF-4 cells, which were derived from a\nsingle donor at different ages over 30 years. Optimization using a function of MethylAger\nsoftware was performed and we demonstrated that it is possible to estimate the ages from\nmethylation sites for both ASF-4 cells and iPS cells prepared from ASF-4 cells. For ASF-\n4 cells, iPS cells, and all the cells, we were able to select three to eight methylation sites,\nfrom which the donor ages were estimated with a root mean squared error of fewer than 6\nyears. Methylation sites obtained by analysis of EC tend to exist in the vicinity of genes, and\nthese genes contained genes related to aging that have been reported so far. Since it was\npossible to estimate age not only for fibroblasts but also for iPS cells derived from them,\nit is suggested that some age-dependent methylation sites exist even in the iPS cells. It is\nalso suggested that analysis of the epigenetic clock is valuable as a method to identify genes\nrelated to aging involving DNA methylation.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"名古屋女子大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12530109","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-7962","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"堀江, 信之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高橋, 和利"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加治, 和彦"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-10"}],"displaytype":"detail","filename":"kojinkasei65_27-38.pdf","filesize":[{"value":"518.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"kojinkasei65_27-38","url":"https://nagoya-wu.repo.nii.ac.jp/record/4313/files/kojinkasei65_27-38.pdf"},"version_id":"50929885-3e61-42ab-8c4d-49128f9e9fd7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"個人の組織から分離された繊維芽細胞及びそれらから作成されたiPS細胞のエピジェネティッククロック解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"個人の組織から分離された繊維芽細胞及びそれらから作成されたiPS細胞のエピジェネティッククロック解析"},{"subitem_title":"Epigenetic Clock Analysis of Fibroblasts Prepared From a Single Donor and iPS Cells Derived from the Fibroblasts","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"14","path":["235"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-10"},"publish_date":"2019-10-10","publish_status":"0","recid":"4313","relation_version_is_last":true,"title":["個人の組織から分離された繊維芽細胞及びそれらから作成されたiPS細胞のエピジェネティッククロック解析"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-20T15:47:07.348043+00:00"}